The match, which will be played between December 9-12 at Allan Border Field in Brisbane, has been downgraded from a full Australia A first-class fixture so that South Africa can use their full squad. The home side has been selected in conjunction with BBL clubs to minimise disruption to the start of that competition which begins on December 13.
Alongside Wyllie, the 20-year-old Campbell Kellaway, who plays for Victoria, has been selected.
"It's an exciting opportunity for Teague Wyllie and Campbell Kellaway to play alongside and learn from established domestic cricketers against an international team of South Africa's quality," national selector George Bailey said.
CA XI squad Peter Handscomb (capt), Sam Whiteman, Henry Hunt, Tim Ward, Teague Wyllie, Campbell Kellaway, Matthew Kuhnemann, Jake Doran, Jack Clayton, Lawrence Neil-Smith, Chris Tremain, Jordan Buckingham, Liam Hatcher