Lunch England 657 and 46 for 2 (Crawley 24*, Root 4*) lead Pakistan 579 (Babar 136, Imam 121, Shafique 114, Salman 53) by 124 runs
After Jacks cleared up Pakistan's tail following an hour-and-a-half worth of resistance led by Salman's 53 to leave Pakistan with a 78-run first-innings deficit, the home side made early inroads as England stretched their advantage to 124 runs by lunch.
The visitors kept the tempo high, in keeping with their first-innings display and aggressive ethos and were 46 for 2 after seven overs of their second innings with Zak Crawley on 24 and Joe Root not out on 4.
Naseem Shah snared the wicket of Ben Duckett - one of England's four centurions in the first innings - for a first-ball duck trying to steer through deep third but picking out Salman at second slip.
Naseem could have had a second when Crawley, who had just hit him for back-to-back fours through the leg side in the fifth over, sent a leading edge back towards the bowler, who got his left hand to it on his follow-through but couldn't hold on.
Straight away, however, on the first ball of the next over, Naseem made amends when he swallowed a catch at deep backward square to remove Ollie Pope, who had skied Mohammad Ali's superb bouncer.
Jacks, called up as a late replacement for Ben Foakes who was struck down by illness on the eve of the match, ended up bowling more than he ever would have imagined with fellow debutant and part-time spinner Liam Livingstone out of action with a knee injury sustained earlier in the match. Jacks sent down down 40.3 overs - second behind only frontline spinner Jack Leach's 49 - and walked away with 6 for 161 in this high-scoring Test.
Jacks, the 24-year-old big-hitter came into the game with just 21 first-class wickets, began the day with three more to his name - including that of Pakistan captain Babar Azam. After the hosts resumed on 499 for 7 in response to England's first-innings 657, Jacks took care of the rest.
Salman, on 10 overnight, helped himself to 16 off the third over of the day, swinging Leach through square leg for four off the first ball before dispatching the last two for six down the ground and four through midwicket, respectively.
He struck back-to-back fours off Jacks a short time later to move deep into the 30s and brought up his second Test fifty with a well-placed chip off Leach over the covers which raced to the boundary. But Salman fell a short time later, edging Jacks to Crawley at slip.
The dismissal brought in Test debutant Haris Rauf, who was cleared to bat but won't bowl in England's second innings after suffering a thigh strain rolling over the ball while fielding on the first day.
Zahid Mahmood, another of Pakistan's four Test debutants in this match, put on a steadfast 17 off 48 balls before he tried to reverse sweep Jacks and was stumped by Pope, acting wicketkeeper in Foakes' absence.
Rauf was the last man out, chasing a wider Jacks delivery and edging to Root, who took a strong catch stretching high overhead at slip.
Valkerie Baynes is a general editor at ESPNcricinfo