England 256 (Sciver 85, Wyatt 35, Jones 32*, Selman 3-29, Matthews 3-56, Schultz 2-52) beat West Indies 105 (Matthews 28, Ecclestone 3-9, Sciver 2-16) by 151 runs
Her 85 off 69 balls to steady England from 84 for 4 took her to 833 ODI runs for 2022 and past Claire Taylor's 2005 mark of 807 despite missing the three matches against India in September. It followed her 96-ball 90 in the first match against West Indies, which marked her return to action.
For the second match in a row, West Indies failed to capitalise after bowling England out inside their 50-over allocation and they have now gone 11 ODI innings without reaching 200.
Cross was extremely economical with 1 for 14 from her seven overs, but left-arm spinner Ecclestone was next-level in that department with 48 dot balls in her nine overs, which yielded three wickets for just nine runs. Offspinner Dean was also frugal with 40 dot balls in eight overs and 1 for 16.
West Indies' run rate nosedived after Matthews' dismissal. Sciver had Kycia Knight caught by Tammy Beaumont and pinned Rashada Williams, who had scored an unbeaten half-century in the second match, lbw either side of Dean's removal of Aaliyah Alleyne, stumped for 8 as West Indies lost three wickets without a run in the space of ten balls.
Sciver clipped a fuller ball from Cherry-Ann Fraser to the boundary through backward square-leg to bring up her 20th ODI fifty. But Matthews brought herself back into the attack in the 28th over and prised out two key wickets, tossing one up to get an advancing Wyatt stumped, before her full, flighted delivery slid under Sciver's attempted slog-sweep and clattered into leg stump.
Selman had bowled Beaumont as England went from 63 for 0 to 65 for 2 and she grabbed her second when she trapped Ecclestone lbw and England wobbled again at 218 for 7.
Matthews enticed Dean with a well-flighted delivery that resulted in a return catch and, after Cross fell to Selman's yorker, Henry - who had seen chances go down off Wyatt and Amy Jones - had Davies caught by Shemaine Campbelle at cover point.
"Any time you come into an ODI series and the top score is 160, you're probably missing out a bit with the bat. It's definitely an area that we need to pay more attention to, find a way to score more runs on the whole"
Hayley Matthews
"We're committing to a style of play and we're fully backed," Jones told BT Sport. "Whilst it's not going to come off every time, we've made three pretty decent scores in this series anyway, so it's definitely a good thing for us going forward. It's something we're going to commit to for sure."
Sciver added: "I'm feeling really good about being back and really positive about being back with this team and with a new coach who's really helped us to see a different way of playing."
Matthews was in no doubt that her side's batting had continued to let them down, having posted totals of 165 and 118 in the first two matches, both of which England won by 142 runs.
"Any time you come into an ODI series and the top score is 160, you're probably missing out a bit with the bat," Matthews said. "It's definitely an area that we need to pay more attention to, find a way to score more runs on the whole, hopefully we can do that in the T20 series coming up. This series was disappointing but as a team I reckon we'll learn from it a whole lot and hopefully we can take some of those learnings into the series we have coming up."
The sides play the first of five T20Is on Sunday in Antigua before moving on to Barbados for the remaining four.
Valkerie Baynes is a general editor at ESPNcricinfo