Flanker Ross Moriarty and scrum-half Gareth Davies return to face France in the Six Nations as Wales coach Wayne Pivac makes two changes.
Moriarty replaces fellow Dragons back-rower Aaron Wainwright, while Davies comes in for Tomos Williams.
Wasps lock Will Rowlands should win his first cap after being named among the replacements.
Fly-half Dan Biggar and wing Josh Adams have been passed fit after suffering injuries in the defeat against Ireland.
Adams picked up a hip problem in the first half of the 24-14 loss, while Biggar failed a head injury assessment in the second half.
Biggar has been in full training since last week and has completed all concussion protocols, with Wales saying they sought the advice of a globally renowned concussion expert who reviewed the fly-half's return.
Wales say Biggar's health has been at the forefront of their decision-making process, stressing player welfare is their top priority.
Pivac also outlined why he had made the changes from the side that was beaten by Ireland.
"Gareth was unavailable round one and came off the bench last time out so he is full of energy and we are looking forward to him bringing his game on Saturday," said Pivac.
"Ross has impressed off the bench so far and brought a lot of energy and communication as well so he deserves an opportunity to start.
"We have changed around the second-rows on the bench - we are looking at creating competition there and Will has trained well and we are looking forward to seeing him out on that stage."
France make one positional and one personnel change to the starting side that defeated Italy 35-22.
Virimi Vakatawa is fit again to play at centre and Gael Fickou moves to wing instead of the injured Vincent Rattez, with Damien Penaud also unfit.
There are four changes on the bench with hooker Camille Chat, prop Jean-Baptiste Gros, flanker Dylan Cretin and full-back Thomas Ramos included.
France and Ireland are the only unbeaten teams in the tournament.
Wales: Halfpenny; North, Tompkins, Parkes, Adams; Biggar, G Davies; W Jones, Owens, D Lewis, Ball, AW Jones (capt), Moriarty, Tipuric, Faletau.
Replacements: Elias, R Evans, Brown, Rowlands, Wainwright, T Williams, J Evans, McNicholl.
France: Bouthier; Thomas, Vakatawa, Vincent, Fickou; Ntamack, Dupont; Baille, Marchand, Haouas, Le Roux, Willemse, Cros, Ollivon (capt), Alldritt.
Replacements: Chat, Gros, Bamba, Taofifenua, Cretin, Serin, Jalibert, Ramos.