Centre Jonathan Joseph is on the wing for his 50th cap as head coach Eddie Jones shuffles England's backline for Sunday's Six Nations game with Ireland.
Elliot Daly moves to full-back for the Twickenham game with George Furbank, who began the first two games, injured.
Centre Manu Tuilagi is back after recovering from a groin niggle.
Prop Joe Marler replaces the unavailable Mako Vunipola, with Ben Youngs returning at scrum-half and Courtney Lawes starting on the flank.
England team to face Ireland
Daly; May, Tuilagi, Farrell (capt), Joseph; Ford, Youngs; Marler, George, Sinckler, Itoje, Kruis, Lawes, Underhill, Curry.
Replacements: Cowan-Dickie, Genge, Stuart, Launchbury, Ewels, Earl, Heinz, Slade.
"We can't wait to get back out there in front of 80,000 people on Sunday," said Jones.
There are four personnel changes from the starting XV that edged past Scotland at Murrayfield a fortnight ago.
In addition to filling the gaps left by the unavailable Vunipola and injured Furbank, Lawes replaces Lewis Ludlam in the back row while Youngs takes over from Willi Heinz at scrum-half.
Henry Slade - who hasn't played since December because of a fractured ankle - returns to the bench.
There are also two locks, Charlie Ewels and Joe Launchbury, among the replacements as Jones again loads his bench with six forwards.
England welcome an Ireland side buoyed by two wins so far in the tournament, with head coach Andy Farrell - father of England captain Owen - taking charge of his first Six Nations campaign.
"Ireland are a very good team, extremely well-coached. They are a team we respect a lot," Jones added.
"They will bring their usual physicality and under Andy Farrell they've opened up their game a little bit.
"They are a tactically smart team. [Conor] Murray and [Johnny] Sexton, who have played 170 Tests between them, at nine and 10 will manage the game well.
"We've got to make sure we match their physicality and their emotion."
Jones has been under fire this week after apologising to a reporter for a joke at a press conference on Thursday.
In response to a question about his meditation practises, after revealing last year how mindfulness exercises were part of his morning routine, Jones said: "You must be thinking about someone else. Maybe another half-Asian person. Maybe we all look the same."
World Cup winning scrum-half Matt Dawson told BBC 5 live the England players could be starting to tire of Jones' behaviour in front of the media.
"My concern is that it will now start to affect the players. He can't help himself," Dawson said.
"The players keep laughing it off and they play it down, but there will come a point when in the back of their minds they will go: 'Eddie, shut up. Stop it. Because you are winding someone up somewhere. You are not helping'."