Leicester Tigers captain Ellis Genge and fly-half George Ford will start their final home game at Welford Road against Northampton Saints in Saturday's Premiership semi-final.
A Tigers win would give prop Genge, who is joining Bristol, and Sale-bound Ford a Twickenham farewell next week.
Juarno Augustus starts at number eight for Saints, one of four changes made by outgoing boss Chris Boyd.
Courtnall Skosan and props Emmanuel Iyogun and Ehren Painter also come in.
The winners will go on to face either Saracens or Harlequins in the final at Twickenham on 18 June.
On what will be an emotional day for Genge and Ford, there will also be a minute's applause in memory of Tiffany Youngs, the wife of former Tigers skipper Tom, who passed away earlier this week.
"I hope everyone realises that however big the game is, it pales into a little bit of insignificance when you look at what has happened this week, so from everyone at Northampton Saints, we'd like to pass our condolences on to Tom and family," Northampton and Wales fly-half Dan Biggar told BBC Look East.
Ben Youngs, Tiffany's brother in-law, will start at scrum-half for Leicester.
Hooker Julian Montoya returns after a month out, while centre Dan Kelly starts in his first appearance since mid-April.
Tigers, who finished top of the table to reach their first semi-final for five years, are looking to reach the Premiership final for the first time in nine years.
'Still early in Tigers' journey'
Tigers head coach Steve Borthwick says there is "plenty for us to improve on", having struggled at the bottom of the table in recent seasons.
"We're still very early in the journey," Borthwick told BBC Radio Leicester.
"You're talking about a club here that very nearly got relegated two years ago - a club that wasn't really respected, was losing most games and the only big games were relegation contests.
"To come back from that, every game is important, every week is important. Can we get better every week? And that's the challenge again this week.
"One of the exciting things is there is so much more for us to do and so much more we as a coaching team and players can work towards here.
"The team has a lot of growth in it, it's a young team, and it's learning quickly from experiences."
Saints 'excited' by semi-final derby
Northampton forwards coach Phil Dowson admits they have endured two "chastening experiences" against their East Midlands rivals so far this season - beaten 55-26 on home soil and 35-20 at Leicester.
But Saints secured a play-off spot on the back of six victories in their last seven Premiership games.
"It feels pretty special," said Dowson, who will succeed Chris Boyd as Saints' rugby director this summer.
"We have worked hard to give ourselves an opportunity in a semi-final, and it's exciting.
"We have taken a hiding twice (against Leicester), and they have been chastening experiences, particularly in a local derby.
"We have to learn our lessons from that and it is clear for us in terms of getting our game on the field and dealing with their very aggressive and dominant performances.
"How we manage to get ourselves into the game is integral to the success of our game-plan. We have to be physical and we have to be disciplined."
Match facts
Line-ups
Leicester Tigers: Steward; Potter, Moroni, Kelly, Porter; Ford, Youngs; Genge (c), Montoya, Cole; Wells, Green, Liebenberg, Reffell, Wiese.
Replacements: Clare, Leatigaga, Heyes, Chessum, Martin, Van Poortvliet, Burns, Nadolo.
Northampton Saints: Freeman; Proctor, Dingwall, Hutchinson, Skosan; Biggar, Mitchell; Iyogun, Matavesi, Painter; Coles, Ratuniyarawa, Lawes, Ludlam (c), Augustus.
Replacements: Haywood, Waller, Heffernan, Ribbans, Hinkley, James, Grayson, Francis.
Referee: Matthew Carley.