Uncapped Northampton full-back Tommy Freeman has been named in England's side to play the Barbarians on Sunday.
Harlequins hooker Jack Walker also makes his first England appearance in the non-cap fixture at at Twickenham.
There is a first start for Gloucester centre Mark Atkinson, while Bath wing Joe Cokanasiga returns after almost a year away.
Scrum-half Danny Care could appear for the first time since November 2018 after being named on the bench.
Courtney Lawes, who captained England in the Six Nations, is also among the replacements, along with Wasps flanker Jack Willis, who suffered a serious knee injury against Italy in February 2021.
The uncapped trio of Will Goodrick-Clarke, Patrick Schickerling and Bath fly-half Orlando Bailey are on the bench, although there is no place for London Irish full-back Henry Arundell.
Saracens and Leicester's players are unavailable as they contest the Premiership final the previous day.
England team
Freeman; Cokanasiga, Marchant, Atkinson, May; Smith, Randall; Rodd, Walker, Collier, Ewels, Hill, Curry, Underhill, Dombrandt.
Replacements: Singleton, Goodrick-Clarke, Schickerling., Lawes, Willis, Care, Bailey, Nowell.
More to follow.