Edinburgh back-row Luke Crosbie makes his first Test start when Scotland take on Argentina in Jujuy on Saturday.
The 25-year-old captained an A-side to victory over Chile last weekend and made his international debut as a replacement against Tonga last year.
Centre Mark Bennett starts his first Scotland game since 2016, while Rory Hutchinson is at full-back.
Lock Grant Gilchrist leads the team for the first time since 2018 in the absence of Stuart Hogg.
Full-back Hogg has been rested for the three-Test tour, along with fellow British & Irish Lions Finn Russell and Chris Harris, while Jamie Ritchie, Adam Hastings and Huw Jones are sidelined by injuries.
Hamish Watson is nursing a shoulder problem but is expected to feature at some stage of the summer tour.
"He's progressing well, but we didn't think it was a risk worth taking this weekend," explained head coach Gregor Townsend of Watson.
Northampton's Hutchinson, usually seen as a centre, last represented his country off the bench in 2020.
Winger Duhan van der Merwe returns after missing the last two games of the Six Nations through suspension.
George Turner gets the nod over Ewan Ashman at hooker having arrived in South America a little later than the full squad following a bout of illness.
After picking up an injury in the Six Nations opener against England, prop Rory Sutherland is on the bench, where is joined by fit-again back-row Rory Darge.
Argentina are ranked eighth in the world, one place below the visitors, but have not beaten Scotland since the 2011 World Cup.
"We're away from home, playing against some of the best individuals in club rugby," added Townsend as the Scots seek a sixth successive victory over the Pumas.
"Argentina have always had brilliant players in the backline and very tough forwards and they seem to have a great crop just now."
Scotland: Hutchinson, Graham, Bennett, Johnson, Van der Merwe, Kinghorn, Price; Schoeman, Turner, Z Fagerson, Gilchrist (capt), Gray, Bradbury, Crosbie, M Fagerson.
Replacements: Ashman, Sutherland, Sebastian, Skinner, Darge, White, Thompson, Tuipulotu.