Russell Westbrook will not be available for the Los Angeles Lakers on Wednesday night against the Nuggets in Dennver because of left hamstring soreness, sources told ESPN's Adrian Wojnawrowski.
Westbrook had been listed as doubtful for the game a day earlier.
Sources previously told Wojnarowski that the veteran point guard remains hopeful of a return vs. the Timberwolves on Friday.
Westbrook was limited to five minutes in the Lakers' preseason finale because of the hamstring and later said that coach Darvin Ham's decision to bring him off the bench in that game could have contributed to the injury.
Westbrook is averaging 10.7 points on 28.9% (8.3% from 3), 6.7 rebounds, 4.3 assists and 2.0 steals per game through the Lakers' 0-3 start to the season.
He was roundly criticized for taking midrange jump shot late in Sunday's loss to the Portland Trail Blazers with 18 seconds left on the shot clock when the Lakers led by one, rather than attacking the rim or working the ball around to an open teammate.
ESPN's Dave McMenamin contributed to this report.