Twenty-one year-old scrum-half Jack van Poortvliet starts ahead of Leicester team-mate Ben Youngs in the England team to face New Zealand on Saturday.
Elsewhere Exeter's Sam Simmonds starts at blindside flanker with Maro Itoje returning to the second row.
Manu Tuilagi is named at outside centre with captain Owen Farrell winning his 100th England cap inside him.
Billy Vunipola starts at eight with Jack Willis providing back-row cover on the bench.
More to follow.
England: Steward; Nowell, Tuilagi, Farrell (capt), May; Smith, Van Poortvliet; Genge, Cowan-Dickie, Sinckler, Itoje, Hill, Simmonds, Curry, Vunipola.
Replacements: George, M Vunipola, Stuart, Ribbans, Willis, Youngs, Porter, Slade