Alex Goode will take banned fly-half Owen Farrell's place in the starting line-up for Saracens' Heineken Champions Cup game against Lyon.
England captain Farrell has been banned for four weeks for a dangerous tackle.
Elliot Daly fills in for Goode at full-back, with Ivan van Zyl at scrum-half, Sean Maitland on the wing and Nick Tompkins starting at 12 on Saturday.
Three-time champions Saracens are third in Pool A after two wins from two, while Lyon are 10th.
That means the French side - who Saracens beat 28-20 when they travelled to France - are outside the qualification places currently.
The top eight teams from each of the two pools advance to the last 16 after four rounds of group games.
Line-ups
Saracens: Daly, Malins, Lozowski, Tompkins, Maitland, Goode, Van Zyl; Mako Vunipola, George (capt), Riccioni, Itoje, Tizard, Christie, Earl, B Vunipola.
Replacements: Woolstencroft, Mawi, Judge, Isiekwe, Dan, Davies, Manu Vunipola, Lewington.
Lyon: Dumortier; Tuisova, Maraku, Godwin, Veredamu; Smith, Pelissie; Kaabeche, Marchand, Gomez-Kodela, Kpoku, Mayanavanua, Cretin, Sobela, Botha.
Replacements: Coltman, Taofifenua, Bamba, William, Goujon, Saginadze, Doussain, Arnold.
Match officials
Referee: Andrea Piardi (Italy)
Assistant referees: Alex Frasson and Manuel Bottino (Italy)
TMO: Matteo Liperini (Italy)
Phone: (800) 737. 6040
Fax: (800) 825 5558
Website: 
Email: 
