Kyle Edmund lost to Daniil Medvedev for the second time in six days as the British number one was knocked out of the Cincinnati Masters.
Edmund, 24, suffered a 6-2 7-5 loss on Tuesday after a straight-set defeat at last week's Rogers Cup in Montreal.
World number 30 Edmund, who had won their two matches before last week, led the Russian 5-3 in the second set.
World number eight Medvedev, 23, will now face Benoit Paire of France in the second round.
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