Henry Slade will captain Exeter Chiefs in their final Heineken Champions Cup pool match against French club Castres.

Castres are already out, having failed to collect a point from their first three games in Pool A.

Exeter, who are through to the last 16, have made several changes as they look to secure a home tie in the next round.

Harvey Skinner starts at fly-half in place of Joe Simmonds, while Rory O'Loughlin will partner Slade at centre.

In the pack, props James Kenny and Josh Iosefa-Scott come into the starting line-up and lock forward Jannes Kirsten also start.

Jack Nowell - left out of England's Six Nations squad earlier this week - retains his place on the wing.

Line-ups

Exeter: Hodge, Nowell, Slade (c), O'Loughlin, Woodburn, Skinner, S Maunder; Kenny, Innard, Iosefa-Scott, Kirsten, Jenkins, Ewers, Tshiunza, S Simmonds.

Replacements: Frost, Sio, Williams, Sunne, Fisilau, J Maunder, J Simmonds, Kata.

Castres: Dumora, Bouzerand, Seguret, Cocagi, Larregain, Botica, Kockott; Tichit, Barlot, Chilachava, Maravat, Vanverberghe, Babillot (c), Delaporte, Tukino.

Replacements: Humbert, Tierney, Azar, Kornath, Pieterse, Ben-Nicholas, Blanc, Chabouni.

Match officials

Referee: Andrew Brace (Ireland)

Touch judges: Peter Martin, Oisin Quinn (both Ireland)

TMO: Leo Colgan (Ireland)