Ollie Smith and Blair Kinghorn will start in place of Stuart Hogg and Finn Russell in Scotland's final Six Nations home match against Italy on Saturday.
Full-back Hogg and fly-half Russell were ruled out after sustaining injuries in Sunday's defeat by Ireland.
Richie Gray drops out after being withdrawn early at Murrayfield, with Sam Skinner taking over at lock.
Captain Jamie Ritchie moves to openside to accommodate Hamish Watson on the blindside as Matt Fagerson is benched.
Ewan Ashman, Rory Sutherland, WP Nel, Ben Healy and Cameron Redpath are added to the squad as replacements, while Jamie Bhatti, Simon Berghan and Chris Harris miss out.
Gregor Townsend's side won their opening two matches in the championship before defeats by France and Ireland.
Edinburgh's Kinghorn has featured off the bench in Scotland's four Six Nations matches this year, while Glasgow Warriors' Smith will make his first appearance of the championship.
Watson came on against Ireland and started in Paris, where Skinner featured as a replacement.
Scotland: Smith, Steyn, H Jones, Tuipulotu, Van der Merwe, Kinghorn, White; Schoeman, Turner, Z Fagerson, Skinner, J Gray, Ritchie (capt), Watson, Dempsey.
Replacements: Ashman, Sutherland, Nel, Cummings, M Fagerson, Price, Healy, Redpath.
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