Gloucester make three changes to the side narrowly beaten by Newcastle for their Heineken Champions Cup last-16 tie at defending champions La Rochelle.
Billy Twelvetrees starts at fly-half, while Mayco Vivas makes his first club start at prop and academy graduate Jack Clement is named at number eight.
Seb Atkinson, who signed a new deal with the Premiership club this week, retains his place at inside centre.
Wing Jules Favre will make his 100th appearance for the French side.
France number eight Gregory Alldritt will captain the hosts, while Jonathan Danty will play at 12 after impressing for Les Blues in the Six Nations.
La Rochelle are one of three sides who have won all four of their games in this season's competition.
Gloucester are struggling in ninth in the Premiership table and reached the knockout stages by finishing eighth from Pool A - the final qualification spot.
Teams
Gloucester: Carreras; Rees-Zammit, Harris, Atkinson, Thorley; Twelvetrees, Varney; Vivas, Blake, Gotovtsev, Clarke, Alemanno, Ackermann, Ludlow (c), Clement.
Replacements: Walker, Elrington, Ford-Robinson, Jordan, Thomas, Morgan, Chapman, May
La Rochelle: Dulin; Thomas, Rhule, Danty, Favre; Hastoy, Kerr-Barlow; Sclavi, Bourgarit, Atonio, Lavault, Skelton, Dillane, Botia, Alldritt (c).
Replacements: Lespiaucq, Wardi, Colombe Reazel, Sazy, Tanga, Boudehent, Berjon, Reus.
Phone: (800) 737. 6040
Fax: (800) 825 5558
Website: 
Email: 
