Great rivals Manchester United and Liverpool are set for a blockbuster FA Cup quarterfinal clash after both teams made it though their fifth-round matchups on Wednesday.

The two heavyweights were paired with each other in Wednesday's draw, but the matchup was only confirmed after Manchester United saw off the challenge of Nottingham Forest and a young Liverpool team got the better of Southampton.

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In another all-Premier League clash, FA Cup holders Manchester City will host Newcastle United.

Elsewhere, eight-time winners Chelsea will face Championship leaders Leicester City and Wolves will host Coventry City.

It is the meeting between 12-times winners Man United and eight-time victors Liverpool that will be the tier of the round, however. United left it late to confirm their part in the matchup, with Casemiro's late header delivering a 1-0 in over Forest.

Liverpool, despite a long list of injuries, made easier work of Championship outfit Southampton, winning 3-0.

Holders City booked their place in the last eight with an emphatic 6-2 victory over Luton Town, in which Erling Haaland became the first top-division player to score five goals in an FA Cup game since George Best struck six for Manchester United against Northampton Town in 1970.

Newcastle and Leicester City also sealed their spots on Tuesday, the former requiring a penalty shootout against Blackburn Rovers and the latter needing extra time to get past Bournemouth.

Coventry, currently ninth in the Championship, are the lowest-ranked side left in this season's competition after dispatching sixth-tier Maidstone United in the fifth round.

The quarterfinals will take place over the weekend of March 16.

FA Cup quarterfinal draw:
Wolves vs. Coventry City
Man United vs. Liverpool
Chelsea vs. Leicester City
Manchester City vs. Newcastle United