CLEVELAND -- The Naylor brothers turned National Siblings Day into quite a family affair.

Josh Naylor and his younger brother, Bo, both hit home runs in the same inning Wednesday night for the Cleveland Guardians in their 7-6 win over the Chicago White Sox.

Josh Naylor connected for a solo homer with one out in the fourth off Chicago's Erick Fedde, and Bo Naylor smashed a two-run shot to center field two batters later.

It was the second time the Naylors homered in the same inning, having done it July 14 last season at Texas.

Before the Naylors connected last season, the last brothers to homer in the same inning were B.J. and Justin Upton for Atlanta in 2013.

The Naylors are the sixth pair of brothers since 1900 to each hit a home run in the same inning since 1900, and the fourth to do it multiple times, joining the Uptons, Billy and Cal Ripken, and Lloyd and Paul Waner.

The only pair to do it as opponents is Rick and Wes Ferrell in 1933. Wes Ferrell hit a home run for Cleveland in the top of the fourth inning, and in the bottom, Rick Ferrell hit a home run for Boston off his brother, who was pitching.

The Associated Press contributed to this report.