PARIS -- Novak Djokovic was bothered by his right knee, then found himself down a set and a break, before doing what he does so well, coming back to beat No. 23 Francisco Cerundolo 6-1, 5-7, 3-6, 7-5, 6-3 in the French Open's fourth round on Monday for his record 370th win in a Grand Slam match.

Djokovic, the defending champion at Roland Garros, broke a tie with Roger Federer for the most match wins at major tournaments -- and also for the most Slam quarterfinals for a man by reaching the 59th of his career.

And the No. 1-ranked Djokovic did it in ways he has so often over his years of dominance and 24 major trophies, both turning around a contest after trailing and emerging when the tension is greatest.

This victory across more than 4 1/2 hours means that Djokovic is now 40-11 in fifth sets over his career.

For Djokovic, it was the second consecutive match that lasted more than 4 hours. In the third round, he also fell behind in sets 2-1 but made his way past No. 30 Lorenzo Musetti, a 22-year-old from Italy, finishing Sunday after 3 a.m., the latest finish in French Open history.

This time, against Cerundolo, a 25-year-old from Argentina who was trying to reach his first Grand Slam quarterfinal, the 37-year-old Djokovic again used all of his skills, experience and ability to adjust on the fly. He came through, in part, by playing more aggressively and putting extra speed on his groundstrokes, while dealing with whatever was going on with his knee.

Djokovic trailed 4-2 in the fourth set but surged from there.

At 2-1 in the fifth set, Djokovic's feet gave way as he chased a ball to his right, and he rolled on the ground, caking his white shorts, his red shirt and parts of his arms and legs with the rust-colored clay. As he walked to the sideline to grab a bottle of water to help clean off, he gave a piece of his mind to anyone who would listen, renewing an earlier complaint about wanting the court to be swept to improve traction.

"Well done, supervisor and everybody," Djokovic said, his voice drenched in sarcasm. "Not slippery at all."

Yet he was just fine at 3-all in that set, when he stretched and slid, doing the splits, while somehow getting his racket on the ball for a drop volley to win a point. His chest on the ground, Djokovic stuck out both arms, mimicking an airplane, and smiled.

The first signs of trouble came much earlier, in the second set, when Djokovic began flexing his right leg. He took a medical timeout and laid down on a towel placed on the sideline, where a trainer massaged that knee, then had Djokovic flip onto his belly to work on his hamstring.

Djokovic winced as his right leg was manipulated, a scene repeated at subsequent changeovers.

During play, Djokovic stumbled occasionally. Or limped a bit. After some lengthier points, he leaned on his racket or bent at the waist and rested with his hands on his knees or crouched.

When he missed a backhand that allowed Cerundolo to convert a break point for the first time in 13 tries, Djokovic handed over the second set. Soon, Djokovic was staring at a two-sets-to-one hole. And not long after that, he was down 4-2 in the fourth.