PHILADELPHIA -- It took an extra three weeks, but Joel Embiid's regular season finally is underway.

The superstar center made his season debut Tuesday night at Wells Fargo Center against the New York Knicks after missing the first nine games due to left knee injury management and then a three-game suspension for shoving a media member.

And after a predictably up-and-down performance across 26 minutes -- 13 points on 2-for-11 shooting from the field (but 8 for 8 from the foul line), plus three rebounds, five assists and a block - in a 111-99 loss, Embiid said it will time for the confidence in exploding off his troublesome left knee to return.

"It's all about confidence and trusting myself," he said. "Pushing off ... I talked about it a couple weeks ago when I talked to you guys, that's the mental hurdle that I got to get to. But I think I can still be pretty good even without that, which I'm going to get to at some point.

"I don't know when. Might be next game, might be in two games ... [but] usually get it back pretty fast, so I'm fine."

Not much is fine these days with the 76ers (2-8), who now sit in 14th place in the Eastern Conference standings with a matchup against the undefeated Cleveland Cavaliers on tap Wednesday. It remains to be seen whether Embiid or fellow star Paul George will play.

Previously, the 76ers have made it clear they'll plan to prioritize the health of their veteran stars over the course of the season. But that was also before their injury-riddled start, as Embiid, George (bone bruise in his left knee) and Tyrese Maxey (hamstring strain) all have been hurt.

"I think it's all about us just getting on the floor together, learning how to play with each other," Embiid said. "But health is a big thing. I'm back, PG is feeling pretty good, now we need to get Tyrese back, and once we're all on the floor, I think we're going to have a pretty good chance to win some games."

The Knicks (5-5) don't have those issues. They've had the same starting lineup -- Jalen Brunston, Josh Hart, Mikal Bridges, OG Anunoby and Karl-Anthony Towns -- plus sixth man Deuce McBride available for each of their first 10 games.

And while this night began with so much attention on Embiid making his season debut, it quickly shifted to Towns - the central New Jersey native playing his first game in the rivalry -- having one of his best all-around performances as a Knick.

Towns immediately scored eight points in the opening few minutes, finished with 21 points, 13 rebounds and 6 assists, and set the tone with his energy at both ends throughout.

"Yeah, obviously Joel is a great defensive player," Knicks forward Josh Hart said. "But first game back, it takes you a little while to get into the rhythm. [Towns] did what we needed him to do, came out of the gate, got a couple of 3s, attacked the rim, played how we needed him to do. Set the tone early, got big rebounds and we kind of fed off of that."

Embiid hadn't played in a competitive game since the U.S. won gold at the Paris Olympics in August. He hadn't played for the 76ers since the Knicks ousted them in Game 6 of the first round of the playoffs here in April.

And against the Knicks on Tuesday night, he looked like a player who had spent significant time away from the court.

His typical touch on his jumper eluded him, and he finished 1 for 5 on 3-pointers. His face-up game, too, was a beat slow, with Towns repeatedly having success getting his hands on the ball when Embiid was trying to load up for a drive and causing him to have to reset.

And playing against Towns and a Knicks offense that often had five players outside the 3-point line, Embiid spent much of the night moving around the court trying to keep up with New York's offensive firepower.

"He was certainly rusty," 76ers coach Nick Nurse said. "Conditioning I think showed up fairly early. Seen him play through that before, kind of respond in the second half, after being on a layoff. Seemed to do it a little bit, then I thought he got kind of tired again in the fourth. But again, probably to be expected. I thought he played with some pretty good competitive spirit for what he could do out there."

Ultimately, though, the result was yet another loss for the 76ers. And while the forgiving Eastern Conference standings, where only the Boston Celtics and Cavaliers currently are over .500, gives a team like Philadelphia time to get things together, it's hoping that process can start now that Embiid has returned.

"The season's long," George said. "I do think once we get all of our pieces together we will start making strides in the right direction. We'll start to get some consistency and the chemistry will continue to take off. Right now, it's Joel's [Embiid] first game back, Tyrese [Maxey] is still out, so we've yet to see this team complete. Those are big pieces for us.

"We're all trying to do a little more than we're supposed to be doing, which is OK because we're trying to fill in big voids and big gaps, but once we're full strength I think that's when we can judge how we are."