From the win over Canada that secured England's WXV1 title success in October, Mitchell has made seven changes in personnel and some positional alterations to his starting XV to face Italy.

Mitchell refused to use the word 'rotation' to describe his selections. Instead, his approach is "one team operating as two".

Lock Zoe Aldcroft captains the side for the first time since Mitchell replaced Marlie Packer as skipper, with Packer taking up her new role as vice-captain from open-side flanker.

Gloucester-Hartpury's Mia Venner is rewarded for her fine Premiership Women's Rugby form with a spot on the wing for a first cap in five years, while full-back Emma Sing will hope to show why a high-percentage goal-kicker needs to be in a World Cup squad.

Exeter Chiefs' Claudia MacDonald, who has recovered from a second serious neck injury, will be keen to show a reminder of her skills that were integral in England's run to the World Cup final in 2022.

Lock Lilli Ives Campion is another player making her first start for the Red Roses, while GB Sevens player Jade Shekells and Exeter scrum-half Flo Robinson could make their debuts off the bench.

Helena Rowland has been tasked with driving the side from fly-half, despite playing the majority of her rugby for England in the midfield.

"We've got to use the competition for places to our advantage," the New Zealander added. "2025 starts with the end [a World Cup final] in mind.

"It's important to realise we'll need two teams to operate this year to play 13 Test matches."

Despite falling to a 48-0 defeat in last year's opening Six Nations game to England, Italy forced their opponents into multiple first-half errors and were behind by only 10 points at half-time.

Italy picked up only one win in that campaign and following two victories from three games at WXV2, they made the bold decision to replace Giovanni Raineri as head coach with Fabio Roselli.

The unknown nature of Roselli's side could throw up fresh questions for England and offer some important on-field problem solving.

"Researching him and his coaching group, they like attacking rugby so I think we'll see an Italian side that will want to express itself early," Mitchell added.

"They will have been influenced by his leadership and I'm sure they'll want to impress him."