Brady Quinn and Pete Prisco break down the pivotal NFC matchup between the New Orleans Saints and San Francisco 49ers. Pete Prisco wonders is it back to back road games if you never go home between games (1:00) Pete picks the Saints to win by at least a touchdown (1:40) Brady Quinn actually thinks Drew Brees will be an issue for the Saints and picks the 49ers to win (2:10) Have the 49ers beat any good teams? (3:35) Will Jimmy Garoppolo be able to move the ball against the Saints defense? (3:45) Can the 49ers run the ball against the Saints rush defense? (4:08) Sportsline expert and Pick Six Podcast Host Will Brinson gives his pick and betting advice for the 49ers Saints game in Week 14 (4:55) Will Brinson believes Alvin Kamara is in line for a big game (6:30) Sportsline expert John Breech gives his pick and gambling advice on the matchup (7:04) John says Jimmy Garoppolo is going to struggle against the Saints defense (7:50) SUBSCRIBE TO OUR CHANNEL: https://www.youtube.com/user/CBSSports FOLLOW US ON: Facebook - https://www.facebook.com/CBSSports/ Instagram - https://www.instagram.com/cbssports/ Twitter - https://twitter.com/CBSSports #NFL #Saints #49ers #Week14Picks #DrewBrees #JimmyG #JimmyGaroppolo #NewOrleans #NewOrleansSaints #Niners #SanFrancisco #SanFrancisco49ers #SanFranciscoNiners #NFLPicks