Liverpool captain Jordan Henderson is a doubt for the Premier League title run-in and Champions League round of 16 second leg after coach Jurgen Klopp confirmed he is out for three weeks because of injury.

England midfielder Henderson was substituted 80 minutes into Liverpool's 1-0 Champions League defeat to Atletico Madrid on Tuesday after dropping to the turf in discomfort.

"Hendo, it could have been worse," Klopp told a news conference on Friday. "It was a hamstring. You have different hamstring injuries now in the Premier League.

"[Harry] Kane, he will be out for three months or so, which isn't cool. But we were still lucky.

"Hendo is exceptionally important, not just football-wise, [but] it's a position where we can react, so we will react.

"Hopefully nothing else happens [to our midfielders] -- we still have options. There's a chance for all of them. But Hendo wouldn't have played every game between now and the end of season."

The European champions' 1-0 defeat to Atletico came in the first leg of the round of 16, with the return fixture at Anfield scheduled for March 11, close to Henderson's expected return date.

Liverpool have several domestic fixtures before then, including an FA Cup fifth-round tie against Chelsea.

Klopp's side, who next play on Monday against West Ham, have a 22-point lead over second-placed Manchester City in the Premier League.