Northampton resume the Premiership season without World Cup winner Cobus Reinach after his move to Montpellier, so Alex Mitchell starts at scrum-half.
David Ribbans returns at lock after an ankle injury for his first Saints appearance since January.
Wasps scrum-half Ben Vellacott and new signing Ryan Mills could make their debuts off the bench.
Captain Joe Launchbury makes his first Wasps appearance since January, having been on England duty before lockdown.
He also injured his knee on that most recent outing against Bordeaux-Begles in the European Challenge Cup.
Northampton and Wasps were fourth and fifth respectively in the Premiership when the season was suspended in March because of the coronavirus pandemic, and are in the batch of clubs hoping to secure a top-four finish in their nine remaining regular-season matches.
Northampton: Furbank; Mallinder, Dingwall, Francis, Tuala; Biggar, Mitchell; van Wyk, Haywood, Hill, Ribbans, Ratuniyarawa, Lawes, Ludlam, Harrison (capt).
Replacements: Matavesi, Hobbs-Awoyemi, Franks, Coles, Tonks, Taylor, Proctor, Naiyaravoro.
Wasps: Minozzi; Kibirige, Fekitoa, Gopperth, Bassett; Umaga, Robson; Harris, Taylor, Brookes, Launchbury (capt), Rowlands, Willis, Young, Shields
Replacements: Oghre, West, Toomaga-Allen, Gaskell, Vailanu, Vellacott, Sopoaga, Mills.
Phone: (800) 737. 6040
Fax: (800) 825 5558
Website: 
Email: 
