Wasps secured a home semi-final in the Premiership play-offs with a bonus-point win over depleted leaders Exeter, who had already clinched top spot.
Tries from Jacob Umaga, Dan Robson and Jimmy Gopperth, who finished with a 19-point haul, put the hosts 25-0 up.
The bonus point Wasps required was secured three minutes after the interval when Josh Bassett crossed.
Chiefs prop Danny Southworth rumbled over on his Premiership debut but Ben Vellacott's double added further gloss.
It meansWasps will return to the Ricoh Arena next weekend to host either Bristol, who moved into third after a bonus-point win at London Irish, or Sale, if they earn a bonus-point win over Worcester on Wednesday in their rearranged final game.
Against a Chiefs side with three players making their first starts - none of the side that started last week's Champions Cup semi-final win over Toulouse were involved - Wasps were quickly into their stride.
Gopperth landed two penalties to make it 6-0 before fly-half Umaga sliced through to grab the opening try with an acrobatic pirouette over the Chiefs line.
Scrum-half Robson pounced on Sam Maunder's loose pass to Don Armand to intercept and sprint away for the second.
Gopperth converted both to give Wasps a commanding 18-0 lead and then powered through two tacklers to stretch over himself just before the interval.
Exeter began the second half brightly but when they lost the ball in the Wasps 22, first Gopperth and then full-back Matteo Minozzi kicked ahead for Bassett to score.
Replacement prop Southworth ploughed over from close range for a memorable personal landmark but Wasps swiftly reasserted themselves.
The predatory Vellacott dotted down from a metre out after the pack did the hard yards before the replacement scrum-half finished off a slick move for his second try with eight minutes left.
Wasps: Minozzi; Kibirige, Fekitoa, Gopperth, Bassett; Umaga, Robson (capt); McIntyre, Taylor, Brookes, Rowlands, Gaskell, Shields, Young, Willis
Replacements: Oghr , West, Toomaga-Allen, Cardall, Barbeary, Vellacott, Le Bourgeois, Miller
Exeter: Dollman; Wyatt, Baldwin, Hendrickson, Cuthbert; Skinner, Maunder; Kenny, Innard, Street, Witty, Dennis, Capstick, Armand (capt), Wright
Replacements: Taione, Southworth, Petch, Price, Pearson, Townsend, Walsh, Short