Real Madrid are facing a defensive crisis after both first-choice centre backs Sergio Ramos and Raphael Varane went off with suspected injuries playing for their countries on Tuesday.

Ramos was substituted in the 43rd minute of Spain's 6-0 win over Germany in Seville in the UEFA Nations League.

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A brief statement from the Spanish football federation said that the defender was suffering from "severe discomfort in his right hamstring."

Varane was replaced at half time of France's 4-2 victory over Sweden in Paris, also seemingly with a hamstring issue.

"I had to take Raphael off because he had a little problem," Les Bleus coach Didier Deschamps said.

The extent of Ramos' injury will be assessed on Wednesday, when the 34-year-old will undergo further tests.

Spain's medical team want to see how the injury evolves overnight before making a definitive diagnosis.

Ramos -- who became the most capped European player ever on Saturday, breaking Italy keeper Gianluigi Buffon's record -- was featuring in his 178th international.

The Real Madrid and Spain captain now looks certain to miss his club's La Liga match with Villarreal on Saturday.

He would then face a race to be fit for a crucial Champions League clash away at Internazionale next Wednesday.

As well as Ramos and Varane, Madrid are also currently without third-choice centre back Eder Militao, who tested positive for the coronavirus on Nov. 2.

If the absence of all three is confirmed, that would leave Nacho Fernandez -- only just back from injury himself -- as the club's only available senior central defender this weekend.