Harlequins climbed back into the Premiership play-off places with an eight-try demolition of Worcester.
Danny Care scored the game's first try before scores from Marcus Smith, Andre Esterhuizen and Wilco Louw saw Quins secure a bonus point in 32 minutes.
Flanker Will Evans scored two tries either side of half-time, with winger Tyrone Green and replacement Luke Northmore also going over for Quins.
Worcester scored twice late on to earn a four-try bonus point of their own.
The tries from wing Alex Hearle and replacement prop Richard Palframan and first-half scores from hooker Niall Annett and lock Joe Batley at least gave Worcester something to show from their afternoon.
But they were well beaten and slumped to a 13th defeat of the season to stay seven points adrift at the bottom of the table.
Harlequins were fresh for the game having selected a much-changed side to the one that lost to Ulster in the Challenge Cup - a defeat which afforded them a week off.
They took advantage by returning with a rampant display to keep their bid for a semi-final firmly on course.
The pick of their tries was perhaps Evans' first, as he was sent away down the right wing and dived to the corner, touching down just before Worcester scrum-half Francois Hougaard could tackle him into touch.
Harlequins: Brown; Green, Marchant, Esterhuizen, Murley; Smith, Care; Marler, Baldwin, Louw, Symons, Lamb, Lawday, Evans, Dombrandt (capt).
Replacements: Gray, Els, Collier, Tizard, Kenningham, Landajo, Herron, Northmore.
Worcester: Shillcock; Humphreys, Lawrence, Venter, Hearle; Searle, Hougaard; Waller, Annett, Schonert , Batley, G Kitchener, Hill (capt), Kvesic, Van Velze.
Replacements: Miller, Thomas, Palframan, Bresler, Dodd, Simpson, Beck, Doel.
Referee: Craig Maxwell-Keys (RFU).