Wasps recall Malakai Fekitoa for the last day of the regular Premiership season, while Rob Miller replaces the injured Charlie Atkinson at full-back.
Josh Bassett plays his 150th game for the club - and Tommy Taylor, Kieran Brookes, Simon McIntyre and Will Rowlands make farewell appearances.
Argentine hooker Julian Montoya has his first Leicester start since February.
Prop Ellis Genge is captain, with Johnny McPhillips and Zach Henry making their final appearances for Tigers.
Wasps were also forced into one late change, when replacement flanker Alfie Barbeary was ruled out, with Tom Cruse being promoted to the bench.
Sixth-placed Leicester are one point and one place above Wasps, but neither side can finish higher than sixth.
Wasps: Miller, Watson, Fekitoa, Le Bourgeois, Bassett; Umaga, Robson; McIntyre, Taylor, Brookes, Rowlands, Gaskell, Willis, Shields (capt), Vailanu.
Replacements: Cruse, Harris, Toomaga-Allen, Cardall, Oghre, Vellacott, Gopperth, De Jongh.
Leicester: Henry, Steward, Scott, Kelly, Nadolo; McPhillips, Van Poortvliet; Genge (capt), Montoya, Cole, Wells, Henderson, Martin, Liebenberg, Wiese.
Replacements: Clare, Whitcombe, Heyes, Lavanini, Chessum, B Youngs, Moroni, Murimurivalu.
Phone: (800) 737. 6040
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