Columbus Crew opened the scoring on Brayan Angulo's own goal in the fourth minute and the defending MLS champions beat Cruz Azul of Mexico 2-0 on Wednesday night in the Campeones Cup.
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Jonathan Mensah scored in the 74th on a header to seal it.
Cruz Azul won LIGA MX's Campeon de Campeones to qualify for the game.
Atlanta United beat Club America 3-2 in 2019 the last time the event was played.