Uruguay have qualified for a fifth Rugby World Cup but Canada will miss out for the first time after a surprise defeat over two legs by Chile.
Canada won the first game 22-21 but were beaten 33-24 in the second as Chile kept alive their hopes of reaching the finals for the first time.
Chile now face the United States in a two-leg play-off for a place at the 2023 tournament in France.
The US were beaten 50-34 over two legs by Uruguay.
After losing 19-16 in the first leg, the South American side ran out 34-15 winners in the second.
Uruguay will be in the same pool as hosts France, New Zealand and Italy at the 2023 World Cup while the winner of Chile v USA will go into pool D with England, Japan, Argentina and Samoa.
Canada, who held a one-point advantage after a 22-21 win in the first leg were well beaten in the return match in Valparaiso.
"This is a hugely disappointing result," said Rugby Canada chief Allen Vansen. "We all know the expectations for Canadian rugby are rightfully higher."
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