Argentina started without Lionel Messi but a moment of magic from Angel Di Maria was enough to give them a barely deserved 1-0 win over Uruguay in Friday's World Cup qualifier in Montevideo.

Uruguay surrendered meekly to Argentina in a 3-0 defeat last month but this time they took the game to their opponents and will feel aggrieved at emerging pointless after having more of the chances in front of their home fans.

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"Sometimes you just have to win and we managed that," Argentine coach Lionel Scaloni said. "Not playing well, certainly, but it still counts."

However, one moment of brilliance from Di Maria was enough to settle the match.

Young Uruguayan left back Joaquin Piquerez lost possession on the edge of the penalty area after six minutes and Di Maria curled a sublime shot over helpless keeper Fernando Muslera.

Luis Suarez had already forced Emiliano Martinez into a good save at the other end and the Atletico Madrid striker also hit the post after half an hour.

The second half was more even and both keepers had to make important saves but Uruguay's lack of firepower -- they have now scored only two goals in their last five games -- meant they struggled against a typically solid Argentine team.

Goalkeeper Martinez was also fortunate in the dying minutes when first Julian Alvarez put a free header over the bar and then the keeper fumbled a long range shot but was able to recover before it crept into the net behind him.

Messi, who missed his last two Paris Saint-Germain games through injury, replaced Giovani Lo Celso with 14 minutes left for Argentina but made little impact for a side that saw their unbeaten streak increase to 26 games, a run that stretches back more than two years.

"They put pressure on us, they have experienced players, but we were lucky to be able to maintain our unbeaten run and get all three points," defender Nicolas Otamendi said.

"We know how difficult it is to play here and we knew that they were under a lot of pressure to win. We had to be strong when the game got complicated but we were able to keep a clean sheet."

The three points takes them on to 28 points, six behind Brazil, who on Thursday became the first South American team to guarantee their place in Qatar 2022 after beating Colombia 1-0.

The top four teams qualify automatically for the finals and the fifth-placed side go into an inter-regional playoff.

Uruguay remain on 16 points, fourth equal with Chile and Colombia.

They head to Bolivia to face the home side at high altitude on Tuesday, while Argentina are at home to Brazil the same night.