In-form France host England in Paris on Saturday aiming to win their first title and Grand Slam since 2010.
France could even be crowned champions before kick-off if Ireland fail to beat Scotland in the day's second game.
England are hoping to avoid losing three matches in a Six Nations for the third time under Eddie Jones after finishing fifth in 2018 and 2021.
England's 14 men showed plenty of fight against Ireland last week but need to win to take the pressure off Jones.
Defeat could bring another fifth-place finish under the Australian and result in questions about head coach's future with the World Cup in France 18 months away.
In a selection termed as a "total surprise" by World Cup winner Matt Dawson, George Furbank will start at full-back for England, with Freddie Steward moved to the wing.
"Furbank's first start for England was in this fixture two years ago where he did not have a good day and to think that won't be rattling around is head is utter nonsense," Dawson said on the Rugby Union Daily podcast.
"He's a lovely runner for Northampton when he has space but I can't work out where Furbank's form is to take over from Steward at full-back.
"Eddie Jones is trying to be clever. I still don't think it will define his career or whether he is still in his position going into the World Cup if England do get turned over, but it is a very confusing selection."
France, who were pushed to the limit by Wales last week, have won their last seven Tests and are gathering momentum as they eye victory in their home World Cup.
None of the French players have experienced a Grand Slam game before, but head coach Fabien Galthie led France to a Grand Slam in 2002 and Shaun Edwards won three as a coach with Wales.
Team news
Wing Damian Penaud returns to France's side after missing last week with Covid-19 and replaces the injured Yoram Moefana.
On the bench, lock Romain Taofifenua also returns from Covid-19 and replaces winger Matthis Lebel as France opt for a six-two forwards-back split.
Aside from bringing in Furbank at full-back and switching Steward to the wing, Jones has made four other changes to his starting team.
Scrum-half Ben Youngs starts with Harry Randall moving to the bench.
Prop Will Stuart replaces Kyle Sinckler who is on the bench, lock Nick Isiekwe is recalled with Charlie Ewels banned and flanker Sam Underhill replaces the injured Tom Curry.
Commentator's notes
Andrew Cotter: "Look to the skies in Paris on Saturday night because that is where much of the game will be played. For all their brilliant strike-running ability and a back-line boosted by the return of Penaud, this French unit is one with patience and a plan. They kick more than any other side, waiting for their moment.
"Jones therefore wants as many players as possible who can compete for the high ball - hence Furbank coming in at full-back which allows Steward to take his imposing presence on to the wing.
"Up front, England will of course miss the injured Curry, but there is a very timely return from Underhill to remind us what he can do.
"Of course the home side will start as clear favourites at a raucous Stade de France, but expectation has a history of weighing France down and the record in this fixture does show that the sight of the white shirts can seem to affect Les Bleus.
"Everybody knows how well France can play but this game will tell us much more about how they can deliver under pressure."
View from both camps
France assistant coach Shaun Edwards: "England are a world-class team who I thought were absolutely outstanding with 14 players against Ireland.
"Any team with Ellis Genge and Maro Itoje is going to be formidable. We know we're in for a battle royal. Add to that this is France's biggest match since the 2011 World Cup final, a chance to win a trophy for the first time in 12 years.
"There's pressure but if you're playing at this level and you can't take pressure, you're in the wrong place. You should be doing something else. You have to enjoy the spotlight, relish the heat. A day like this is what you play rugby for."
England head coach Eddie Jones: "We are disappointed not to be in the contention for the trophy but last week's effort against Ireland was full of pride, energy and tactical discipline.
"We have focused on refreshing the team this week and we are ready to empty the tank on Saturday."
England captain Courtney Lawes: "It's a very hostile crowd at the Stade de France and you have to be prepared for that.
"It's part and parcel of playing away from home on the international stage, especially against a team going for the Grand Slam. That's absolutely fine for us. We can use it for motivation and use it to give us energy.
"You have to change the mentality of the crowd. It was similar at Murrayfield where we were getting booed on the way in. You have got to prove these people wrong and essentially try to make them quiet.
Line-ups
France: 15-Jaminet; 14-Penaud, 13-Fickou, 12-Danty, 11-Villiere; 10-Ntamack, 9-Dupont (capt); 1-Baille, 2-Marchand, 3-Atonio, 4-Woki, 5-Willemse, 6-Cros, 7-Jelonch, 8-Alldritt
Replacements: 16-Mauvaka, 17-Gros, 18-Haouas, 19-Taofifenua, 20-Flament, 21-Cretin, 22-Lucu, 23-Ramos.
England: 15-Furbank; 14-Steward, 13-Marchant, 12-Slade, 11-Nowell; 10-Smith, 9-Youngs; 1-Genge, 2-George, 3-Stuart, 4-Itoje, 5-Isiekwe, 6-Lawes (capt), 7-Underhill, 8-Simmonds.
Replacements: 16-Dolly, 17-Marler, 18-Sinckler, 19-Chessum, 20-Dombrandt, 21-Randall, 22-Ford, 23-Daly.
Match facts
Head-to-head
France
England
Match officials
Referee: Jaco Peyper (South Africa)
Touch judges: Mike Adamson (Scotland) & Frank Murphy (Ireland)
TMO: Marius Jonker (South Africa)