Arsenal slipped to a shock 2-1 defeat against Brighton at the Emirates Stadium on Saturday as their hopes of finishing in the top four took a huge blow.
Leandro Trossard and Enock Mwepu scored a goal in each half and although Martin Odegaard pulled one back late on, Mikel Arteta's side suffered their second consecutive loss in the Premier League.
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Brighton had failed to score in their last three matches but produced an impressive display to claim their first league win away from home since February.
Arsenal remain in fifth place but could fall three points behind rivals Tottenham Hotspur if Antonio Conte's side earn a victory at Aston Villa later on Saturday..
Mikel Arteta rejigged the Arsenal starting lineup due to injuries and midfielder Granit Xhaka started at left back, a decision that gave Arsenal no control in midfield and no cohesion in attack in the first half.
Brighton took the lead after 28 minutes when Trossard was through on goal and produced a fine finish past Aaron Ramsdale.
The hosts thought they had equalised on the stroke of half-time but Gabriel Martinelli's goal was ruled out for offside after a lengthy VAR check.
Arsenal started the second-half brightly but found themselves 2-0 down after 67 minutes when Mwepu's stunning half-volley flew into the bottom corner.
Odegaard grabbed a goal back for Arsenal in the 89th minute but they failed to complete the comeback and suffered a disappointing loss.
"I'm glad we won today, we needed the three points. Coming from six defeats is not easy," Mwepu said.
"We really believe in ourselves, we have the right mentality in the group and we showed what we could do today. The gameplan was to win."