Will Evans comes in for Tom Lawday at openside flanker as Harlequins attempt to overhaul a 14-point deficit to French high-fliers Montpellier and make the Champions Cup last eight.
Andre Esterhuizen and Joe Marchant form a strong centre pairing in the backs.
English number eight Zach Mercer drops to the bench for Montpellier.
The 24-year-old scored two tries and was named man of the match in his team's 40-26 victory last weekend.
Springbok Handre Pollard comes into the visiting team, but at inside centre rather than his usual fly-half role. France international Guilhem Guirado is back at hooker.
If Harlequins can complete their comeback at the Stoop, they will face more French opposition in the quarter-finals with either last year's runners-up La Rochelle or Bordeaux-Begles lying in wait.
La Rochelle lead 31-13 on aggregate before their home leg and are favourites to progress.
What they say
Harlequins scrum coach Adam Jones: "I think if you look back at our results over the last 18 months or so it's clear to see that it's never over.
"The first-half performance wasn't good enough, but to be only fourteen points down overall with the score being 34-0 after 50 minutes is not too bad.
"Montpellier probably felt they needed more of a 21-point lead so I'm sure they'll be a bit frustrated, but we know they are still going to be tough opponents back at the Stoop."
Match stats
Line-ups
Harlequins: Jones; Lynagh, Marchant, Esterhuizen, Murley; Smith, Care; Marler, Walker, Collier, Symons, Tizard, Hammond, Evans, Dombrandt (capt.)
Replacements: Gray, Kerrod, Louw, Jurevicius, Wallace, Gjaltema, Edwards, David
Montpellier: Tisseron; Ngandebe, Reilhac, Pollard, Lucas; Foursans, Eymeri; Nariashvili, Guirado, Thomas, Verhaeghe, Willemse, Ouedraogo, Camara, Becognee.
Replacements: Maurouard, Rodgers, Lamositele, Mercer, Doan, Doumayrou, Bouthier, Chalureau